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The Involvement of Prolactin in Stress-Related Disorders.

Authors :
Faron-Górecka A
Latocha K
Pabian P
Kolasa M
Sobczyk-Krupiarz I
Dziedzicka-Wasylewska M
Source :
International journal of environmental research and public health [Int J Environ Res Public Health] 2023 Feb 13; Vol. 20 (4). Date of Electronic Publication: 2023 Feb 13.
Publication Year :
2023

Abstract

The most important and widely studied role of prolactin (PRL) is its modulation of stress responses during pregnancy and lactation. PRL acts as a neuropeptide to support physiological reproductive responses. The effects of PRL on the nervous system contribute to a wide range of changes in the female brain during pregnancy and the inhibition of the hypothalamic-pituitary axis. All these changes contribute to the behavioral and physiological adaptations of a young mother to enable reproductive success. PRL-driven brain adaptations are also crucial for regulating maternal emotionality and well-being. Hyperprolactinemia (elevated PRL levels) is a natural and beneficial phenomenon during pregnancy and lactation. However, in other situations, it is often associated with serious endocrine disorders, such as ovulation suppression, which results in a lack of offspring. This introductory example shows how complex this hormone is. In this review, we focus on the different roles of PRL in the body and emphasize the results obtained from animal models of neuropsychiatric disorders.

Details

Language :
English
ISSN :
1660-4601
Volume :
20
Issue :
4
Database :
MEDLINE
Journal :
International journal of environmental research and public health
Publication Type :
Academic Journal
Accession number :
36833950
Full Text :
https://doi.org/10.3390/ijerph20043257