Healthy Vaccinee Bias and MenB-FHbp Vaccine Effectiveness Against Gonorrhea.

Authors :: Abara WE
Bernstein KT
Lewis FMT
Pathela P
Islam A
Eberhart M
Cheng I
Ternier A
Sanderson Slutsker J
Madera R
Kirkcaldy R
Source :: Sexually transmitted diseases [Sex Transm Dis] 2023 Jun 01; Vol. 50 (6), pp. e8-e10. Date of Electronic Publication: 2023 Mar 02.
Publication Year :: 2023
Abstract: Abstract: Observational studies demonstrated 30% to 40% effectiveness of outer-membrane vesicle (OMV) meningococcal serogroup B vaccines against gonorrhea. To explore whether healthy vaccinee bias influenced such findings, we examined the effectiveness of MenB-FHbp, a non-OMV vaccine that is not protective against gonorrhea. MenB-FHbp was ineffective against gonorrhea. Healthy vaccinee bias likely did not confound earlier studies of OMV vaccines.<br />Competing Interests: Conflict of Interest and Sources of Funding: None declared.<br /> (Copyright © 2023 American Sexually Transmitted Diseases Association. All rights reserved.)