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Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan.
- Source :
-
Nature aging [Nat Aging] 2023 Feb; Vol. 3 (2), pp. 157-161. Date of Electronic Publication: 2022 Dec 30. - Publication Year :
- 2023
-
Abstract
- Mitochondrial dysfunction plays a central role in aging but the exact biological causes are still being determined. Here, we show that optogenetically increasing mitochondrial membrane potential during adulthood using a light-activated proton pump improves age-associated phenotypes and extends lifespan in C. elegans . Our findings provide direct causal evidence that rescuing the age-related decline in mitochondrial membrane potential is sufficient to slow the rate of aging and extend healthspan and lifespan.<br />Competing Interests: Competing Interests B.J.B, S.P. and A.P.W. are listed as inventors on a patent application based on some of the work described here. The remaining authors declare no competing interests.
Details
- Language :
- English
- ISSN :
- 2662-8465
- Volume :
- 3
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nature aging
- Publication Type :
- Academic Journal
- Accession number :
- 36873708
- Full Text :
- https://doi.org/10.1038/s43587-022-00340-7