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Bile salt hydrolase of Lactiplantibacillus plantarum plays important roles in amelioration of DSS-induced colitis.
- Source :
-
IScience [iScience] 2023 Feb 13; Vol. 26 (3), pp. 106196. Date of Electronic Publication: 2023 Feb 13 (Print Publication: 2023). - Publication Year :
- 2023
-
Abstract
- Bile salt hydrolases are thought to be the gatekeepers of bile acid metabolism. To study the role of BSH in colitis, we investigated the ameliorative effects of different BSH-knockout strains of Lactiplantibacillus plantarum AR113. The results showed that L. plantarum Δ bsh 1 and Δ bsh 3 treatments did not improve body weight and alleviate the hyperactivated myeloperoxidase activity to the DSS group. However, the findings for L. plantarum AR113, L. plantarum Δ bsh 2 and Δ bsh 4 treatments were completely opposite. The double and triple bsh knockout strains further confirmed that BSH 1 and BSH 3 are critical for the ameliorative effects of L. plantarum AR113. In addition, L. plantarum Δ bsh 1 and Δ bsh 3 did not significantly inhibit the increase in pro-inflammatory cytokines or the decrease in an anti-inflammatory cytokine. These results suggest that BSH 1 and BSH 3 in L. plantarum play important roles in alleviating enteritis symptoms.<br />Competing Interests: The authors declare no competing interests.<br /> (© 2023 The Author(s).)
Details
- Language :
- English
- ISSN :
- 2589-0042
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- IScience
- Publication Type :
- Academic Journal
- Accession number :
- 36895642
- Full Text :
- https://doi.org/10.1016/j.isci.2023.106196