Reply to letter to the editor by Yoshii.

Competing Interests: Conflict of interest KE is affiliated with, and KN supervise the Department of Musculoskeletal Regenerative Medicine, Osaka University, Graduate School of Medicine, which is supported by Taisho. KE has received payments for lectures from Amgen, Asahi-Kasei, Astellas, Chugai, Daiichi Sankyo, Eisai, Eli Lilly, Ono, and Pfizer, and received consultant fee from Asahi-Kasei. KE and MH have received research grants from Amgen, Asahi-Kasei, Astellas, Chugai, Daiichi Sankyo, Eisai, Eli Lilly, and Ono. YN has received payments for lectures from Asahi-Kasei, Astellas, Chugai, Daiichi Sankyo, Eisai, Eli Lilly, and Ono. HT has received payments for lectures from Asahi-Kasei, Astellas, Chugai, Eisai, Eli Lilly, and Pfizer, and has received a research grant from Chugai. JH have received payments for lectures from Chugai, and research grants from Astellas, Chugai, and Eisai. HY have received research grants from Astellas, Daiichi Sankyo, Eisai, and MSD. KN has received a research grant from Astellas. SO declare that he has no conflicts of interest.