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Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer's Disease.

Authors :
Golas AC
Salwierz P
Rajji TK
Bowie CR
Butters MA
Fischer CE
Flint AJ
Herrmann N
Mah L
Mulsant BH
Pollock BG
Taghdiri F
Wang W
Tartaglia MC
Source :
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2023; Vol. 92 (4), pp. 1219-1227.
Publication Year :
2023

Abstract

Major depressive disorder (MDD) is a risk factor for Alzheimer's disease (AD). Cerebrovascular disease (CVD) is implicated in MDD and AD. Our study compared participants with AD positive and negative cerebrospinal fluid (CSF) biomarkers on neuropsychological performance, remitted MDD status, and CVD burden. Next, we compared AD-CSF biomarkers and white matter hyperintensities (WMH) burden among three groups: mild cognitive impairment (MCI) (n = 12), MCI with remitted MDD (MDD+MCI) (n = 12), and remitted MDD alone (MDD) (n = 7). Few participants (18%) with MCI+MDD exhibited AD(+) biomarkers. Nearly all participants had moderate-severe WMH. WMH may contribute to cognitive impairment or depression in MCI patients with AD(-) biomarkers.

Details

Language :
English
ISSN :
1875-8908
Volume :
92
Issue :
4
Database :
MEDLINE
Journal :
Journal of Alzheimer's disease : JAD
Publication Type :
Academic Journal
Accession number :
36911939
Full Text :
https://doi.org/10.3233/JAD-221097