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Compounds isolated from the pericarp of Zanthoxylum bungeanum and inhibitory activity against LPS-induced NO production in RAW264.7.
- Source :
-
Journal of Asian natural products research [J Asian Nat Prod Res] 2023 Oct; Vol. 25 (10), pp. 1012-1020. Date of Electronic Publication: 2023 Mar 14. - Publication Year :
- 2023
-
Abstract
- Seventeen compounds were isolated and identified from the ethyl acetate part of Zanthoxylum bungeanum Maxim., including one new compound 18-acetyloxyneocryptotanshinone ( 1 ) and 16 known compounds ( 2-17 ). Their structures were elucidated by extensive spectroscopy. The absolute configuration of 1 was confirmed by electronic circular dichroism (ECD). All compounds were evaluated for the inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, of which 1 and 10 exhibited the most significant inhibitory effect, with IC <subscript>50</subscript> of 17.29 and 10.27 μ M, respectively.
- Subjects :
- Nitric Oxide
Lipopolysaccharides pharmacology
Macrophages
Zanthoxylum chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1477-2213
- Volume :
- 25
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of Asian natural products research
- Publication Type :
- Academic Journal
- Accession number :
- 36916389
- Full Text :
- https://doi.org/10.1080/10286020.2023.2188203