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Colchicine reduces the activation of NLRP3 inflammasome in COVID-19 patients.

Authors :
Amaral NB
Rodrigues TS
Giannini MC
Lopes MI
Bonjorno LP
Menezes PISO
Dib SM
Gigante SLG
Benatti MN
Rezek UC
Emrich-Filho LL
Sousa BA
Almeida SCL
Luppino-Assad R
Veras FP
Schneider AH
Leiria LOS
Cunha LD
Alves-Filho JC
Cunha TM
Arruda E
Miranda CH
Pazin-Filho A
Auxiliadora-Martins M
Borges MC
Fonseca BAL
Bollela VR
Del-Ben CM
Cunha FQ
Santana RC
Vilar FC
Zamboni DS
Louzada-Junior P
Oliveira RDR
Source :
Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2023 May; Vol. 72 (5), pp. 895-899. Date of Electronic Publication: 2023 Mar 14.
Publication Year :
2023

Abstract

Objective: To evaluate whether colchicine treatment was associated with the inhibition of NLRP3 inflammasome activation in patients with COVID-19.<br />Methods: We present a post hoc analysis from a double-blinded placebo-controlled randomized clinical trial (RCT) on the effect of colchicine for the treatment of COVID-19. Serum levels of NOD-like receptor protein 3 (NLRP3) inflammasome products-active caspase-1 (Casp1p20), IL-1β, and IL-18-were assessed at enrollment and after 48-72 h of treatment in patients receiving standard-of-care (SOC) plus placebo vs. those receiving SOC plus colchicine. The colchicine regimen was 0.5 mg tid for 5 days, followed by 0.5 mg bid for another 5 days.<br />Results: Thirty-six patients received SOC plus colchicine, and thirty-six received SOC plus placebo. Colchicine reduced the need for supplemental oxygen and the length of hospitalization. On Days 2-3, colchicine lowered the serum levels of Casp1p20 and IL-18, but not IL-1β.<br />Conclusion: Treatment with colchicine inhibited the activation of the NLRP3 inflammasome, an event triggering the 'cytokine storm' in COVID-19.<br />Trial Registration Numbers: RBR-8jyhxh.<br /> (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Details

Language :
English
ISSN :
1420-908X
Volume :
72
Issue :
5
Database :
MEDLINE
Journal :
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Publication Type :
Academic Journal
Accession number :
36917217
Full Text :
https://doi.org/10.1007/s00011-023-01718-y