Hypoxia-circular RNA crosstalk to promote breast cancer.

Authors :: Karami Fath M
Shafieyari S
Ardalani N
Moumivand F
Kaviani Charati H
Zareei M
Mansoori Nia A
Zokaei M
Barati G
Source :: Pathology, research and practice [Pathol Res Pract] 2023 Apr; Vol. 244, pp. 154402. Date of Electronic Publication: 2023 Mar 05.
Publication Year :: 2023
Abstract: The expression of hypoxia-inducible factors (HIFs), particularly HIF-1, plays a major role in the adaptation of solid tumors to hypoxic conditions. The activation of the HIF pathway results in an expression of genes involved in the promotion of cell growth, proliferation, vascularization, metastasis, and therapeutic resistance. Circular RNA (CircRNA) is considered as a major regulator of gene expression. CircRNAs could regulate the HIF-1 pathway in cancer cells. In addition, they might be regulated by the HIF-1 pathway to promote cancer progression. Therefore, the crosstalk between hypoxia and circRNA might be involved in the pathogenesis of cancers, including breast cancer. In this review, we discussed the function of HIF-related circRNAs in the progression, angiogenesis, metabolic reprogramming, and stemness maintenance of breast cancer. In addition, the correlation between HIF-related circRNAs and clinical features of breast cancer is reviewed.<br />Competing Interests: Conflict of interest The authors declare no conflict of interest.<br /> (Copyright © 2023 Elsevier GmbH. All rights reserved.)