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DNA sensing in the pathological process of ischemic stroke.

Authors :
Zhang SW
Wu CR
Liao H
Source :
The European journal of neuroscience [Eur J Neurosci] 2023 Apr; Vol. 57 (8), pp. 1432-1441. Date of Electronic Publication: 2023 Mar 23.
Publication Year :
2023

Abstract

The innate immune response plays an important role in the pathological process of ischemic stroke. Increasing evidence suggests that the inflammatory response triggered by the innate immune system hinders neurological and behavioural recovery after stroke. The perception of abnormal DNA and its downstream effects are an essential part of the innate immune system. The abnormal DNA is the major inducing factor for innate immune response and is sensed by a series of DNA sensors. In this review, we discussed the multiple roles of DNA sensing in the pathological process of ischemic stroke, with a special focus on DNA sensors Toll-like receptor 9 (TLR9), absent in melanoma 2 (AIM2) and cyclic GMP-AMP synthase (cGAS).<br /> (© 2023 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)

Details

Language :
English
ISSN :
1460-9568
Volume :
57
Issue :
8
Database :
MEDLINE
Journal :
The European journal of neuroscience
Publication Type :
Academic Journal
Accession number :
36932672
Full Text :
https://doi.org/10.1111/ejn.15967