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Multiple myeloma with t(11;14): impact of novel agents on outcome.

Authors :: Puertas B
González-Calle V
Sobejano-Fuertes E
Escalante F
Rey-Bua B
Padilla I
García-Sanz R
Puig N
Gutiérrez NC
Mateos MV
Source :: Blood cancer journal [Blood Cancer J] 2023 Mar 20; Vol. 13 (1), pp. 40. Date of Electronic Publication: 2023 Mar 20.
Publication Year :: 2023
Abstract: Multiple myeloma (MM) patients with t(11;14) present unique biological features and their prognosis is not well established. We report a retrospective study of 591 MM patients, 17.3% of whom had t(11;14). It was designed to determine the prognostic impact of this abnormality and the effect of novel agents on the response and outcomes. Three groups were established based on their cytogenetics: (1) t(11;14); (2) high-risk chromosomal abnormalities; and (3) standard risk (SR). After 80.1 months (1.2-273.8 months) of follow-up, no differences were observed in overall survival (OS) between the t(11;14) and SR groups (75.8 vs. 87.2 months; P = 0.438). Treatment of MM t(11;14) with novel agents did not improve their overall response rate (ORR) or complete response (CR) compared with those who received conventional therapy (ORR: 87.2 vs. 79.5%, P = 0.336; CR: 23.4 vs. 12.8%, P = 0.215). This effect translated into a similar PFS (39.6 vs. 30.0 months; P = 0.450) and OS (107.6 vs. 75.7 months; P = 0.175). In summary, MM t(11;14) patients did not benefit from the introduction of novel agents as much as SR patients did, indicating that other therapies are needed to improve their outcomes.<br /> (© 2023. The Author(s).)