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High-contrast spectroscopic photoacoustic characterization of thermal tissue ablation in the visible spectrum.
- Source :
-
Ultrasonography (Seoul, Korea) [Ultrasonography] 2023 Apr; Vol. 42 (2), pp. 249-258. Date of Electronic Publication: 2022 Nov 29. - Publication Year :
- 2023
-
Abstract
- Purpose: High-contrast tissue characterization of thermal ablation has been desired to evaluate therapeutic outcomes accurately. This paper presents a photoacoustic (PA) characterization of thermal tissue ablation in the visible spectrum, in which higher light absorbance can produce spectral contrast starker than in the near-infrared range.<br />Methods: Ex vivo experiments were performed to measure visible PA spectra (480-700 nm) from fresh porcine liver tissues that received a thermal dose in a range of cumulative equivalent minutes at 43°C (CEM43). The local hemoglobin lobe area between 510-600 nm and wholespectral area under the curve were evaluated to represent the transition of hemoglobin into methemoglobin (MetHb) in the target tissue.<br />Results: The thermal process below an estimated therapeutic CEM43 threshold (80-340 minutes) presented a progressive elevation of the PA spectrum and an eventual loss of local hemoglobin peaks in the visible spectrum, closer to the MetHb spectrum. Interestingly, an excessive CEM43 produced a substantial drop in the PA spectrum. In the spectral analysis, the visible spectrum yielded 13.9-34.1 times higher PA sensitivity and 1.42 times higher contrast change than at a near-infrared wavelength.<br />Conclusion: This novel method of PA tissue characterization in the visible spectrum could be a potential modality to evaluate various thermal therapeutic modalities at high-contrast resolution.
Details
- Language :
- English
- ISSN :
- 2288-5919
- Volume :
- 42
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Ultrasonography (Seoul, Korea)
- Publication Type :
- Academic Journal
- Accession number :
- 36935599
- Full Text :
- https://doi.org/10.14366/usg.22171