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Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 May 01; Vol. 87, pp. 129256. Date of Electronic Publication: 2023 Mar 24. - Publication Year :
- 2023
-
Abstract
- Kir6.2/SUR1 is an ATP-regulated potassium channel that acts as an intracellular metabolic sensor, controlling insulin and appetite-stimulatory neuropeptides secretion. In this Letter, we present the SAR around a novel Kir6.2/SUR1 channel opener scaffold derived from an HTS screening campaign. New series of compounds with tractable SAR trends and favorable potencies are reported.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)
- Subjects :
- Sulfonylurea Receptors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 87
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 36966977
- Full Text :
- https://doi.org/10.1016/j.bmcl.2023.129256