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The Impact of a Very Short Abstinence Period on Assisted Reproductive Technique Outcomes: A Systematic Review and Meta-Analysis.

Authors :
Barbagallo F
Cannarella R
Crafa A
La Vignera S
Condorelli RA
Manna C
Calogero AE
Source :
Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 Mar 20; Vol. 12 (3). Date of Electronic Publication: 2023 Mar 20.
Publication Year :
2023

Abstract

Background: Previous studies supported the beneficial effects of a very short abstinence period on sperm quality. This systematic review and meta-analysis aimed to evaluate the effects of a very short abstinence period (within 4 h) on assisted reproductive technique (ART) outcomes.<br />Methods: A literature search was performed using the Pubmed, Scopus, Web of Science, and Cochrane databases. A meta-analysis was performed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) for randomized controlled trials (RCTs). All eligible studies were selected following the PICOS (Population, Intervention, Comparison/Comparator, Outcomes, Study type) model. The following pregnancy outcomes after ART were considered: fertilization rate (FR), implantation rate (IR), clinical pregnancy rate (CPR), live birth rate (LBR), and miscarriage rate (MR). This study was registered on PROSPERO (CRD42023396429).<br />Results: We evaluated 414 records for eligibility, and 7 studies were ultimately included. Our analysis showed that a very short abstinence period significantly increased the IR, CPR, and LBR after ART. No significant differences were found for the FR and MR.<br />Conclusions: A second ejaculation collected very shortly after the first one could represent a simple strategy to improve the results of ART, especially in couples including patients with abnormal sperm parameters.

Details

Language :
English
ISSN :
2076-3921
Volume :
12
Issue :
3
Database :
MEDLINE
Journal :
Antioxidants (Basel, Switzerland)
Publication Type :
Academic Journal
Accession number :
36979001
Full Text :
https://doi.org/10.3390/antiox12030752