TREM2: A new player in the tumor microenvironment.

Authors :: Molgora M
Liu YA
Colonna M
Cella M
Source :: Seminars in immunology [Semin Immunol] 2023 May; Vol. 67, pp. 101739. Date of Electronic Publication: 2023 Mar 28.
Publication Year :: 2023
Abstract: TREM2 is a myeloid cell receptor that has been extensively described in the context of neuroinflammation and neurodegenerative diseases. Recently, TREM2 emerged as a crucial regulator of macrophage function in tumors. TREM2-deficiency or blockade provide protection and promote the response to anti-PD1 in different murine models. In human tumors, TREM2-expressing macrophages are present in numerous cohorts and tumor types and are generally associated with immunosuppression and poor prognosis. Here, we provide an overview of the impact of TREM2 in tumors considering current literature, with a focus on both murine models and human cancer.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)