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π-Extended BTD Derivatives: Synthesis, Photophysical Properties, and Applications in Biological Systems Imaging for Discriminating Living and Dead Cells.
- Source :
-
Chemistry, an Asian journal [Chem Asian J] 2023 Jun 01; Vol. 18 (11), pp. e202300038. Date of Electronic Publication: 2023 May 15. - Publication Year :
- 2023
-
Abstract
- Here, π-Extended BTD derivatives were successfully synthesized by Heck coupling reaction, which exhibited the the advantages of simplicity and efficiency, wild substrate scope, easily available substrates and high yield. The fluorescent probe PEG-BTDAr targeting LDs was successfully prepared by the nucleophilic substitution reaction between the Heck coupling reaction product 3 h and Amino polyethylene glycol monomethyl ether (Mn=2000). PEG-BTDAr exhibited the advantages of high selectivity, good stability and pH resistance. The use of PEG as a substrate gave PEG-BTDAr good biocompatibility. It was worth mentioning that PEG-BTDAr could not only track LDs in cells under different physiological conditions, but also distinguish between living and dead cells in biological systems.<br /> (© 2023 Wiley-VCH GmbH.)
- Subjects :
- Polyethylene Glycols chemistry
Diagnostic Imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1861-471X
- Volume :
- 18
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Chemistry, an Asian journal
- Publication Type :
- Academic Journal
- Accession number :
- 36994718
- Full Text :
- https://doi.org/10.1002/asia.202300038