AIDS with obesity, hypothyroidism and elevated serum creatinine: A case report.

Authors :: Zhang C
Qian C
Wang W
Chen Z
Lin Y
Sun M
Source :: Frontiers in medicine [Front Med (Lausanne)] 2023 Mar 14; Vol. 10, pp. 1090659. Date of Electronic Publication: 2023 Mar 14 (Print Publication: 2023).
Publication Year :: 2023
Abstract: Hypothyroidism is a prevalent endocrine illness with a variety of clinical symptoms, but among which elevated serum creatinine is uncommon. Hypothyroidism is also common in acquired immunodeficiency syndrome (AIDS) patients, especially those receiving highly active antiretroviral treatment (HAART). Here we present a case of a young AIDS patient with hypothyroidism, increased serum creatinine, and obesity. Despite the lack of a kidney biopsy, following levothyroxine (LT4) therapy, his serum creatinine recovered to normal levels, and weight loss, edema, weakness, rough skin and other clinical symptoms obtained notable improvement. This highlights the need of clinicians paying attention to whether thyroid function is aberrant in human immunodeficiency virus (HIV) patients with increased creatinine, edema and significant weight gain since prompt thyroid hormone therapy can restore the alterations in renal function and avoid invasive renal biopsy.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2023 Zhang, Qian, Wang, Chen, Lin and Sun.)