Back to Search
Start Over
Cysteine-responsive prodrug of the anti-cancer drug amonafide: fluorogenic adjuvant drug delivery with hydrogen sulfide (H 2 S).
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Apr 18; Vol. 59 (32), pp. 4802-4805. Date of Electronic Publication: 2023 Apr 18. - Publication Year :
- 2023
-
Abstract
- L-Cysteine (Cys)-responsive turn-on fluorogenic prodrug AM-ITC was developed for the adjuvant delivery of the anti-cancer drug amonafide and the gasotransmitter hydrogen sulfide (H <subscript>2</subscript> S) in aqueous and cellular media. Considering the cytoprotective roles of H <subscript>2</subscript> S, the present adjuvant strategy would be helpful in minimizing the anti-cancer drug-induced side-effects.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 59
- Issue :
- 32
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 37000594
- Full Text :
- https://doi.org/10.1039/d3cc00220a