A fluorescent probe based on phenothiazine for detection of ClO - with naked-eye color change properties.

Authors :: Zhang C
Wang Y
Li X
Nie S
Liu C
Zhang Y
Guo J
Source :: Analytical biochemistry [Anal Biochem] 2023 Jun 01; Vol. 670, pp. 115131. Date of Electronic Publication: 2023 Mar 29.
Publication Year :: 2023
Abstract: Hypochlorite (ClO <superscript>-</superscript> ) plays a key role in life systems and it is necessary to develop an effective detection method. In view of the significant advantages of the fluorescent probe, we have synthesized a naked-eye recognition fluorescent probe NNCF for the detection of ClO <superscript>-</superscript> based on phenothiazine and naphthalimide. The probe NNCF is sensitive (LOD = 9.5 nM) and fast for ClO <superscript>-</superscript> (within 30 s), and its Stokes shift is as large as 161 nm. In addition, the probe NNCF has been successfully used for imaging detection of exogenous ClO <superscript>-</superscript> in MCF-7 cells with low toxicity.<br />Competing Interests: Declaration of competing interest There are no conflicts of interest.<br /> (Copyright © 2023 Elsevier Inc. All rights reserved.)

Subjects :: Humans
Eye Color
Phenothiazines
Fluorescent Dyes
Hypochlorous Acid

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