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Do cardiovascular disease comorbidities affect the cognitive function of Multiple Sclerosis patients?
Do cardiovascular disease comorbidities affect the cognitive function of Multiple Sclerosis patients?
- Source :
-
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2023 Jun; Vol. 112, pp. 20-24. Date of Electronic Publication: 2023 Apr 07. - Publication Year :
- 2023
-
Abstract
- Introduction: Cognitive impairment is a core symptom of multiple sclerosis, leading to disability in 40-70% of patients. The most common cognitive domains affected by MS are information processing speed, complex attention, executive functions and less frequently, episodic declarative memory. Cardiovascular disease comorbidities have been shown to increase the decline rate in many neurological conditions. Our study aims to examine the possible impact of CVD risk factors in the cognitive decline rate of PwMS.<br />Methods: Over the course of a year, 248 PwMS with and without Cardiovascular comorbidity were cognitively evaluated using the written version of SDMT and the MoCA.<br />Results: Compared to control, MS patients with comorbid CVD had greater general cognitive decline and decreased processing speed. Patients with comorbid diabetes and dyslipidemia had the highest impairment, followed by those with hypertension, compared to the control group and those patients with a high BMI.<br />Conclusion: The presence of cardiovascular comorbidities and especially dyslipidemia increases the rate of cognitive decline in MS patients. In such cases, patients should be evaluated every 6 months instead of a year and the use of the SDMT is advised since it's time efficient,it requires minimal training and correlates with MRI findings.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Cognition
Comorbidity
Neuropsychological Tests
Multiple Sclerosis complications
Multiple Sclerosis epidemiology
Cardiovascular Diseases complications
Cardiovascular Diseases epidemiology
Cognitive Dysfunction epidemiology
Cognitive Dysfunction etiology
Cognitive Dysfunction diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2653
- Volume :
- 112
- Database :
- MEDLINE
- Journal :
- Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
- Publication Type :
- Academic Journal
- Accession number :
- 37031630
- Full Text :
- https://doi.org/10.1016/j.jocn.2023.04.005