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Comparison of Clinical and Immunological Features of Para- and Non-Paraneoplastic Autoimmune Retinopathy in Chinese - A Series of 48 Cases.
- Source :
-
Ocular immunology and inflammation [Ocul Immunol Inflamm] 2024 Jul; Vol. 32 (5), pp. 664-672. Date of Electronic Publication: 2023 Apr 12. - Publication Year :
- 2024
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Abstract
- Purpose: To characterize and compare clinical and immunological features of para(p)-autoimmune retinopathy (AIR) and non-para(np)-AIR and to assess the clinical significance of the presence of serum anti-retinal antibodies (ARAs).<br />Methods: We retrospectively reviewed 48 Chinese patients with p-AIR or np-AIR who took comprehensive ophthalmic examinations and lab tests of the presence of serum ARAs.<br />Results: p-AIR patients differed from np-AIR patients in terms of disease progression, ocular inflammation, findings of OCT, FFA, and presence of ARAs. No significant difference was found in the band number of serum ARAs between AIR patients and healthy controls. The prevalence of antibodies to recoverin and ɑ-enolase in the sera of p-AIR was significantly higher than that of the healthy individuals.<br />Conclusion: While having many similar clinical signs, patients with p-AIR or np-AIR nevertheless displayed unique characteristics. Detection of ARAs subtypes, rather than their quantity, may be helpful in evaluating the conditions in the verified instances.
- Subjects :
- Adult
Aged
Female
Humans
Male
Middle Aged
Young Adult
Asian People ethnology
Autoantigens immunology
China epidemiology
East Asian People
Fluorescein Angiography methods
Phosphopyruvate Hydratase immunology
Phosphopyruvate Hydratase blood
Retina immunology
Retina pathology
Retrospective Studies
Tomography, Optical Coherence
Autoantibodies blood
Autoimmune Diseases immunology
Autoimmune Diseases diagnosis
Recoverin immunology
Retinal Diseases immunology
Retinal Diseases diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1744-5078
- Volume :
- 32
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Ocular immunology and inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 37043636
- Full Text :
- https://doi.org/10.1080/09273948.2023.2193844