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Endogenous Endophthalmitis at a Tertiary Referral Center in China: A Retrospective Study Over Three Decades.
- Source :
-
Ocular immunology and inflammation [Ocul Immunol Inflamm] 2024 Aug; Vol. 32 (6), pp. 803-812. Date of Electronic Publication: 2023 Apr 24. - Publication Year :
- 2024
-
Abstract
- Purpose: To investigate the etiology, pathogens, treatment, and prognosis of endogenous endophthalmitis (EE).<br />Methods: Patients diagnosed with EE over three decades at Peking Union Medical College Hospital were retrospectively reviewed and analyzed.<br />Results: A total of 97 eyes from 81 patients were included. Diabetes was the most common predisposing medical condition (34.6%). Klebsiella pneumoniae (31.3%) and Candida albicans (32.8%) were the most common pathogens. Liver abscess (20.6%) was the predominant cause EE due to liver abscess had a worse initial visual acuity ( P < 0.05). Patients who initially underwent pars plana vitrectomy (PPV)+silicone oil tamponade underwent fewer total treatments ( P < 0.05). In the past 10 years, the proportion of Gram-positive cocci, Gram-negative bacilli, and Candida showed an upward trend. Over the past 15 years, EE after liver abscess and immunosuppression has increased, while EE from genitourinary systems has decreased.<br />Conclusion: EE was a devastating intraocular disease with a poor visual prognosis. The initial condition and prognosis of EE after liver abscess were the worst. PPV+silicone oil tamponade as an initial treatment may reduce additional therapy.
- Subjects :
- Humans
Retrospective Studies
Male
Female
Middle Aged
China epidemiology
Aged
Adult
Young Adult
Adolescent
Aged, 80 and over
Prognosis
Anti-Bacterial Agents therapeutic use
Incidence
Child
Risk Factors
Follow-Up Studies
Endophthalmitis microbiology
Endophthalmitis epidemiology
Endophthalmitis diagnosis
Tertiary Care Centers statistics & numerical data
Eye Infections, Bacterial microbiology
Eye Infections, Bacterial epidemiology
Eye Infections, Bacterial diagnosis
Eye Infections, Fungal microbiology
Eye Infections, Fungal epidemiology
Eye Infections, Fungal diagnosis
Eye Infections, Fungal therapy
Visual Acuity physiology
Vitrectomy
Subjects
Details
- Language :
- English
- ISSN :
- 1744-5078
- Volume :
- 32
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Ocular immunology and inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 37094073
- Full Text :
- https://doi.org/10.1080/09273948.2023.2198001