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Catalytic asymmetric de novo construction of 4-pyrrolin-2-ones via intermolecular formal [3+2] cycloaddition of azoalkenes with azlactones.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 May 11; Vol. 59 (39), pp. 5902-5905. Date of Electronic Publication: 2023 May 11. - Publication Year :
- 2023
-
Abstract
- The chiral phosphoric acid-catalyzed asymmetric intermolecular formal [3+2] cycloaddition of azoalkenes with azlactones has been established. This convergent protocol leads to a facile and enantioselective de novo construction of a wide range of fully substituted 4-pyrrolin-2-ones bearing a fully substituted carbon atom in good yields and with excellent enantioselectivities (26 examples, 72-95% yields and 87-99% ee).
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 59
- Issue :
- 39
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 37097750
- Full Text :
- https://doi.org/10.1039/d3cc01194a