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The African Turquoise Killifish: A Scalable Vertebrate Model for Aging and Other Complex Phenotypes.
- Source :
-
Cold Spring Harbor protocols [Cold Spring Harb Protoc] 2024 Mar 01; Vol. 2024 (3), pp. 107737. Date of Electronic Publication: 2024 Mar 01. - Publication Year :
- 2024
-
Abstract
- The African turquoise killifish Nothobranchius furzeri is currently the shortest-lived vertebrate that can be bred in captivity. Because of its short life span of only 4-6 months, rapid generation time, high fecundity, and low cost of maintenance, the African turquoise killifish has emerged as an attractive model organism that combines the scalability of invertebrate models with the unique features of vertebrate organisms. A growing community of researchers is using the African turquoise killifish for studies in diverse fields, including aging, organ regeneration, development, "suspended animation," evolution, neuroscience, and disease. A wide range of techniques is now available for killifish research, from genetic manipulations and genomic tools to specialized assays for studying life span, organ biology, response to injury, etc. This protocol collection provides detailed descriptions of the methods that are generally applicable to all killifish laboratories and those that are limited to specific disciplines. Here, we give an overview of the features that render the African turquoise killifish a unique fast-track vertebrate model organism.<br /> (© 2024 Cold Spring Harbor Laboratory Press.)
- Subjects :
- Animals
Biological Assay
Fundulus heteroclitus
Phenotype
Aging
Vertebrates
Killifishes
Subjects
Details
- Language :
- English
- ISSN :
- 1559-6095
- Volume :
- 2024
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cold Spring Harbor protocols
- Publication Type :
- Academic Journal
- Accession number :
- 37100468
- Full Text :
- https://doi.org/10.1101/pdb.over107737