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Decreased Expression of EP3 Receptor mRNA in the Brain of Mouse Model of Autism Spectrum Disorder.
- Source :
-
MicroRNA (Shariqah, United Arab Emirates) [Microrna] 2023; Vol. 12 (3), pp. 221-226. - Publication Year :
- 2023
-
Abstract
- Background: Accumulating evidence has implicated the role of neuroinflammation in the pathology of autism spectrum disorder (ASD), a neurodevelopmental disorder.<br />Objectives: To investigate the expression of prostaglandin EP3 (EP3) receptor mRNA in the brain of ASD mouse model.<br />Methods: Pregnant mice were injected with valproic acid (VPA) 500 mg/kg intraperitoneally at 12.5 d gestation. The offspring were tested at the age of 5-6 weeks old for their social interaction behavior. Each mouse was assessed for prostaglandin EP3 receptor expression in the prefrontal cortical, hippocampal and cerebellar areas one day after the behavioral test.<br />Results: Compared to the naive, mice born to dams treated with VPA demonstrated a significantly shorter duration of sniffing behavior, a model of social interaction. Results further showed that the expression of EP3 receptor mRNA was significantly lower in all three brain regions of the mice born to VPA-treated dams.<br />Conclusion: The present study provides further evidence of the relevance of the arachidonic acid cascade as an essential part of neuroinflammation in the pathology of ASD.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Details
- Language :
- English
- ISSN :
- 2211-5374
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- MicroRNA (Shariqah, United Arab Emirates)
- Publication Type :
- Academic Journal
- Accession number :
- 37106511
- Full Text :
- https://doi.org/10.2174/2211536612666230427152647