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Clinical, Endoscopic, and Histopathologic Gastrointestinal Disease in an American Cohort With Behçet's Disease.
Clinical, Endoscopic, and Histopathologic Gastrointestinal Disease in an American Cohort With Behçet's Disease.
- Source :
-
Clinical and translational gastroenterology [Clin Transl Gastroenterol] 2023 Aug 01; Vol. 14 (8), pp. e00591. Date of Electronic Publication: 2023 Aug 01. - Publication Year :
- 2023
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Abstract
- Introduction: Behçet's disease (BD) is a chronic systemic vasculitis characterized by oral and genital ulcers, uveitis, and skin lesions. Patients with BD may develop gastrointestinal (GI) disease; however, characterization of GI disease in American cohorts is lacking. In this article, we present clinical, endoscopic, and histopathologic GI findings in an American cohort of patients with BD.<br />Methods: Patients with established BD were evaluated prospectively at the National Institutes of Health. Demographic and clinical data were collected including BD manifestations and GI symptoms. Endoscopy with histopathologic sampling was performed for both clinical and research indications with written consent.<br />Results: Eighty-three patients were evaluated. The majority were female (83.1%) and white (75.9%). Mean age was 36 ± 14.8 years. GI symptoms were reported in 75% of cohort with nearly half of reporting abdominal pain (48.2%) and significant numbers reporting acid reflux, diarrhea, and nausea/vomiting. Esophagogastroduodenoscopy was performed in 37 patients; erythema and ulcers were the most common found abnormalities. Colonoscopy was performed in 32 patients with abnormalities including polyps, erythema, and ulcers. Endoscopy was normal in 27% of esophagogastroduodenoscopies and 47% of colonoscopies. Vascular congestion was demonstrated on the majority of random biopsies throughout the GI tract. Inflammation was not highly prevalent on random biopsies except in the stomach. Wireless capsule endoscopy was performed on 18 patients; ulcers and strictures were the most common abnormalities.<br />Discussion: GI symptoms were common in this cohort of American patients with BD. Endoscopic examination was often normal; however, histopathologic examination demonstrated vascular congestion throughout the GI tract.<br /> (Copyright © 2023 Written work prepared by employees of the Federal Government as part of their official duties is, under the U.S. Copyright Act, a “work of the United States Government” for which copyright protection under Title 17 of the United States Code is not available. As such, copyright does not extend to the contributions of employees of the Federal Government.)
- Subjects :
- Humans
Male
Female
United States epidemiology
Young Adult
Adult
Middle Aged
Ulcer
Colonoscopy
Behcet Syndrome complications
Behcet Syndrome diagnosis
Behcet Syndrome pathology
Gastrointestinal Diseases diagnosis
Gastrointestinal Diseases epidemiology
Gastrointestinal Diseases etiology
Capsule Endoscopy
Subjects
Details
- Language :
- English
- ISSN :
- 2155-384X
- Volume :
- 14
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Clinical and translational gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 37114910
- Full Text :
- https://doi.org/10.14309/ctg.0000000000000591