68Ga-PSMA PET/CT Detecting Metastatic Lesion of RCC: Missed on 18F-FDG PET/CT.

Authors :: Jha S
Hemrom A
Shamim SA
Barwad A
Batra A
Source :: Clinical nuclear medicine [Clin Nucl Med] 2023 Jun 01; Vol. 48 (6), pp. e294-e296.
Publication Year :: 2023
Abstract: Abstract: Renal cell carcinoma (RCC) accounts for ~2% of global cancers and deaths. Survival depends on initial staging and shows poor survival rate in metastatic disease. CT and MRI are used for evaluating RCC, and PET/CT is used for metastatic disease assessment. We report a case of RCC, where both 18F-FDG and 68Ga-PSMA PET/CT showed increased uptake in liver metastatic lesions; however, a subhepatic peritoneal deposit showed uptake only in PSMA. Also, liver lesions were seen better in PSMA owing to lesser background uptake, suggesting a possibility of 68Ga-PSMA being a potential tracer for RCC evaluation.<br />Competing Interests: Conflicts of interest and sources of funding: none declared.<br /> (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)