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Dynamic changes in circulating EBV-DNA load during treatment have prognostic values in EBV + DLBCL-NOS: a Chinese cohort study.
- Source :
-
Annals of hematology [Ann Hematol] 2023 Sep; Vol. 102 (9), pp. 2471-2481. Date of Electronic Publication: 2023 May 10. - Publication Year :
- 2023
-
Abstract
- EBV-positive diffuse large B-cell lymphoma, not otherwise specified (EBV <superscript>+</superscript> DLBCL-NOS), is an EBV-positive clonal B-cell lymphoid proliferation and circulating EBV-DNA is a great indicator for prognosis among EBV associated disease. In this retrospective study, we report 66 EBV <superscript>+</superscript> DLBCL cases among 2137 DLBCL-NOS cases diagnosed from 2013 to 2021 (prevalence of 6.0%). After a median follow-up of 27 months, progression-free survival (PFS) and overall survival (OS) at 2 years were 39.5% ± 6.2% and 53.6% ± 6.4%, respectively. Multivariate analysis showed that only the biomarker of the positivity of post treatment EBV-DNA had a borderline correlation with shorter PFS and OS (PFS: P = 0.053; OS: P = 0.065). Patients were divided into three subgroups according to dynamic changes of EBV-DNA status: EBV-DNA persistently negative group, EBV-DNA persistently positive group, and EBV-DNA transformed from positive to negative group; among the three groups, patients of the persistently positive group had worst PFS and OS (P = 0.0527 and P = 0.0139, respectively). Decline in EBV copies correlated significantly with treatment response as well. In conclusion, circulating EBV-DNA level played a vital role in prognostic and monitoring marker for EBV <superscript>+</superscript> DLBCL-NOS.<br /> (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Details
- Language :
- English
- ISSN :
- 1432-0584
- Volume :
- 102
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Annals of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 37160794
- Full Text :
- https://doi.org/10.1007/s00277-023-05260-z