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Clinical impact of carbon-ion radiotherapy on hepatocellular carcinoma with Child-Pugh B cirrhosis.
- Source :
-
Cancer medicine [Cancer Med] 2023 Jul; Vol. 12 (13), pp. 14004-14014. Date of Electronic Publication: 2023 May 10. - Publication Year :
- 2023
-
Abstract
- Background and Aims: Hepatocellular carcinoma (HCC) patients with Child-Pugh (CP)-B not eligible for surgery nor other focal therapy options due to impaired liver function, have very limited treatment options. This study aims to retrospectively investigate the toxicity and efficacy of Carbon-ion radiotherapy (C-ion RT) on HCC with CP-B patients.<br />Materials and Methods: Patients with CP-B, no extrahepatic metastasis, and treated with C-ion RT between May 2000 and March 2020 were retrospectively extracted and included in this study.<br />Results: Sixty-nine lesions of 58 patients were included. The median follow-up duration was 20.5 (2.7-108) months. During follow-up, recurrence was observed in 43 patients, including 2 local recurrences and 39 intrahepatic recurrences beyond the irradiation field. A grade 3 acute hepatotoxicity was observed in one patient during the observation period. No acute or late adverse event of grade ≥4 was observed. Overall survival was 80.4% and 46.0% at 1 and 2 years, respectively, and the median survival time was 22.6 months. Local control rate was 96.4% at both 1 and 2 years, and progression-free survival was 38.6% and 6.9% at 1 and 2 years, respectively, with a median of 9.7 months.<br />Conclusion: The C-ion RT showed low toxicity and good local effect in patients with HCC and CP-B. Therefore, C-ion RT could be an appropriate treatment for patients with HCC with poor liver function.<br /> (© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
- Subjects :
- Humans
Retrospective Studies
Liver Cirrhosis complications
Recurrence
Carbon therapeutic use
Carcinoma, Hepatocellular complications
Carcinoma, Hepatocellular radiotherapy
Carcinoma, Hepatocellular drug therapy
Liver Neoplasms complications
Liver Neoplasms radiotherapy
Liver Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2045-7634
- Volume :
- 12
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Cancer medicine
- Publication Type :
- Academic Journal
- Accession number :
- 37162312
- Full Text :
- https://doi.org/10.1002/cam4.6046