Five undescribed guanidine alkaloids from Plumbago zeylanica.

Authors :: Zheng L
Guo PJ
Zhu Y
Li CY
Wang WQ
Xuan LJ
Source :: Fitoterapia [Fitoterapia] 2023 Jul; Vol. 168, pp. 105538. Date of Electronic Publication: 2023 May 11.
Publication Year :: 2023
Abstract: Five undescribed guanidine alkaloids, plumbagines HK (1-4) and plumbagoside E (5), as well as five known analogues (6-10) were isolated from the roots of Plumbago zeylanica. Their structures were established by extensive spectroscopic analyses and chemical methods. In addition, 1-10 were accessed their anti-inflammatory activities by measuring nitric oxide (NO) concentrations in LPS-induced RAW 264.7 cells. However, all compounds especially 1 and 3-5 could not inhibit the secretion of NO but significant increase the secretion of NO. The result reminded us that 1-10 may become potential novel immune potentiators.<br />Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest.<br /> (Copyright © 2023 Elsevier B.V. All rights reserved.)