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Study on the Interaction between Silibinin and Neuraminidase.

Authors :
Fang H
Ding Y
Lu Y
Niu B
Lu H
Chen Q
Source :
Current pharmaceutical design [Curr Pharm Des] 2023; Vol. 29 (16), pp. 1266-1273.
Publication Year :
2023

Abstract

Background: Neuraminidase is a pathogenic protein of the avian influenza virus. Previous studies have shown that silibinin has the potential to inhibit neuraminidase activity.<br />Objective: This study aims to explore the interaction between silibinin and neuraminidase and the effect of silibinin on the structure and activity of neuraminidase.<br />Methods: In this study, two-dimensional fluorescence spectrum, three-dimensional fluorescence spectrometry, Uv-vis spectroscopy, and circular dichroism analysis were used.<br />Results: Silibinin alters the secondary structure of neuraminidase and inhibits the activity of neuraminidase.<br />Conclusion: Silibinin can interact with neuraminidase and inhibit its activity.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Details

Language :
English
ISSN :
1873-4286
Volume :
29
Issue :
16
Database :
MEDLINE
Journal :
Current pharmaceutical design
Publication Type :
Academic Journal
Accession number :
37190805
Full Text :
https://doi.org/10.2174/1381612829666230515165041