Back to Search Start Over

Efficacy and safety of gefapixant for chronic cough: a meta-analysis of randomised controlled trials.

Authors :
Chuang MH
Chen IW
Chen JY
Kang FC
Ho CN
Wu SC
Yew M
Lan KM
Hung KC
Source :
European respiratory review : an official journal of the European Respiratory Society [Eur Respir Rev] 2023 May 17; Vol. 32 (168). Date of Electronic Publication: 2023 May 17 (Print Publication: 2023).
Publication Year :
2023

Abstract

Background: The efficacy and safety of gefapixant in adults with chronic cough remain unclear. Our objective was to assess the efficacy and safety of gefapixant using updated evidence.<br />Methods: MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL) and Embase databases were searched from inception through September 2022. Subgroup analysis based on dose of gefapixant ( i.e. ≤20, 45-50 and ≥100 mg twice daily for low, moderate and high doses, respectively) was performed to explore a potential dose-dependent effect.<br />Results: Five studies involving seven trials showed the efficacy of moderate- or high-dose gefapixant for reducing objective 24-h cough frequency (estimated relative reduction 30.9% and 58.5%, respectively) ( i.e. primary outcome) and awake cough frequency (estimated relative reduction 47.3% and 62.8%, respectively). Night-time cough frequency was only reduced with high-dose gefapixant. Consistently, the use of moderate- or high-dose gefapixant significantly alleviated cough severity and improved cough-related quality of life, but increased the risk of all-cause adverse events (AEs), treatment-related AEs and ageusia/dysgeusia/hypogeusia. Subgroup analysis showed dose dependency in both efficacy and AEs with a cut-off dose being ≥45 mg twice daily.<br />Conclusions: This meta-analysis revealed dose-dependent efficacy and adverse effects of gefapixant against chronic cough. Further studies are required to investigate the feasibility of moderate-dose ( i.e. 45-50 mg twice daily) gefapixant in clinical practice.<br />Competing Interests: Conflict of interest: The authors declare no conflicts of interest.<br /> (Copyright ©The authors 2023.)

Details

Language :
English
ISSN :
1600-0617
Volume :
32
Issue :
168
Database :
MEDLINE
Journal :
European respiratory review : an official journal of the European Respiratory Society
Publication Type :
Academic Journal
Accession number :
37197770
Full Text :
https://doi.org/10.1183/16000617.0219-2022