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High Dose of Pegylated Interferon for the Treatment of Chronic Hepatitis B in Children Infected With Genotype C.
- Source :
-
JPGN reports [JPGN Rep] 2020 Aug 19; Vol. 1 (2), pp. e005. Date of Electronic Publication: 2020 Aug 19 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Chronic hepatitis B virus (HBV) genotype C infection is unlikely to show a good response to interferon (IFN). However, it is unknown whether a high dose of pegylated IFN (PEG-IFN) treatment would be effective for hepatitis B e antigen (HBeAg)-positive children with chronic HBV genotype C infection.<br />Methods: HBeAg-positive children and adolescents with chronic HBV genotype C infection were eligible for this study. To increase the dose of PEG-IFN, all patients received PEG-IFN-α-2a (180 μg) without dose adjustment on the basis of body surface area for 48 weeks and were followed up for 24 weeks after the completion of treatment.<br />Results: Thirteen patients (median age, 9 years) were enrolled prospectively for this study. One patient dropped out, and the remaining 12 patients were evaluated. Of the 12 patients, 11 received PEG-IFN of 180 μg/1.73 m <superscript>2</superscript> or more (median, 287 μg/1.73 m <superscript>2</superscript> ). Eight (67%) experienced HBeAg seroconversion, and 1 (8%) achieved hepatitis B surface antigen (HBsAg) loss at the end of follow-up. There was a significant difference in the decrease of hepatitis B surface antigen levels from the baseline to week 24 of treatment between the responders and the nonresponders. Serum cytokines and chemokines were measured in 10 patients. The levels of C-X-C motif chemokine ligand 9, 10, 11, and 13 in the responders tended to be higher than those in the nonresponders during the first 24 weeks of treatment.<br />Conclusions: A high dose of PEG-IFN treatment was effective and safe. A decrease in the hepatitis B surface antigen level from baseline to week 24 of treatment might be a predictor of HBeAg seroconversion.<br />Competing Interests: T. Kanto received lecture fees from Gilead Sciences and Merck, Sharp, & Dohme. The remaining authors report no conflicts of interests. The corresponding author is responsible for submitting a competing statement on behalf of all authors of this article.<br /> (Copyright © 2020 The Author(s). Published by Wolters Kluwer on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.)
Details
- Language :
- English
- ISSN :
- 2691-171X
- Volume :
- 1
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- JPGN reports
- Publication Type :
- Academic Journal
- Accession number :
- 37206604
- Full Text :
- https://doi.org/10.1097/PG9.0000000000000005