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Skeletal Editing of (Hetero)Arenes Using Carbenes.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Jul 26; Vol. 29 (42), pp. e202301227. Date of Electronic Publication: 2023 Jul 03. - Publication Year :
- 2023
-
Abstract
- (Hetero)arenes continue to prove their indispensability in pharmaceuticals, materials science, and synthetic chemistry. As such, the controllable modification of biologically significant (hetero)arenes towards diverse more-potent complex molecular scaffolds through peripheral and skeletal editing has been considered a challenging goal in synthetic organic chemistry. Despite many excellent reviews on peripheral editing (i. e., C-H functionalization) of (hetero)arenes, their skeletal editings via single atom insertion, deletion, or transmutations have received less attention in the review literature. In this review, we systematically summarize the state-of-the-art skeletal editing reactions of (hetero)arenes using carbenes, with a focus on general mechanistic considerations and their applications in natural product syntheses. The potential opportunities and inherent challenges encountered while developing these strategies are also highlighted.<br /> (© 2023 Wiley-VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 29
- Issue :
- 42
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 37230933
- Full Text :
- https://doi.org/10.1002/chem.202301227