A step-by-step approach for selecting an optimal minimal important difference.

Competing Interests: Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/disclosure-of-interest/ and declare: no support for the submitted work. AC-L, GHG, and TD have a patent issued for the Credibility instrument for judging the minimal important difference and the Patient Reported Outcome Minimal Important Difference (PROMID) Database (https://www.promid.org). AC-L, CBT, GHG, MW, TAF, and TD report grants, pending patents, personal fees, roles in advisory board or leadership in the committees outside the submitted work; no other relationships or activities that could appear to have influenced the submitted work.