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Effect of antibiotics, antibiotic-resistant bacteria, and extracellular antibiotic resistance genes on the fate of ARGs in marine sediments.
- Source :
-
The Science of the total environment [Sci Total Environ] 2023 Sep 15; Vol. 891, pp. 164305. Date of Electronic Publication: 2023 May 27. - Publication Year :
- 2023
-
Abstract
- Surface runoff is a prevalent source via which emerging pollutants (i.e., antibiotics, antibiotic-resistant bacteria (ARB), and antibiotic resistance genes (ARGs)) enter marine sediments. However, few studies have investigated the effect of emerging pollutants on the fate of ARGs in marine sediments. Therefore, three systems were established to measure the relative abundances of four common ARGs (i.e., bla <subscript>TEM</subscript> , tetA, tetC, and aphA) and the integron-integrase gene (intI1) after exposure to emerging pollutants in marine sediments from the Bohai Sea, the Yellow Sea, the East China Sea, and the South China Sea in China. The results revealed that antibiotic exposure could decrease the relative abundance of most ARGs (including bla <subscript>TEM</subscript> , tetA, and tetC) in these marine sediment samples. The exceptions were the relative abundance of bla <subscript>TEM</subscript> in the Bohai Sea marine sediments under ampicillin exposure and tetC in the Yellow Sea marine sediments under tetracycline exposure, which increased significantly. Among marine sediments challenged with ARB, the relative abundance of aphA in all four marine sediments displayed a decreasing trend, whereas the abundances of bla <subscript>TEM</subscript> and tetA in the marine sediments from the Bohai Sea and the South China Sea showed an increasing trend. The relative abundance of tetA in the marine sediments from the Yellow Sea and the East China Sea dropped markedly when exposed to extracellular ARG (eARG). Significant changes in bla <subscript>TEM</subscript> abundance were observed in the four marine sediments under eARG exposure. Gene aphA abundance showed the same trend as the intI1 abundance. IntI1 showed a decreasing trend under the exposure of antibiotic, ARB, or eARG, apart from the East and the South China Sea marine sediments under ampicillin conditions and the South China Sea marine sediments under RP4 plasmid condition. These findings suggest that dosing with emerging pollutants does not increase ARG abundance in marine sediments.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Subjects :
- Angiotensin Receptor Antagonists pharmacology
Angiotensin-Converting Enzyme Inhibitors pharmacology
Drug Resistance, Microbial genetics
Anti-Bacterial Agents pharmacology
Bacteria genetics
Ampicillin pharmacology
Geologic Sediments microbiology
China
Genes, Bacterial
Environmental Pollutants
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1026
- Volume :
- 891
- Database :
- MEDLINE
- Journal :
- The Science of the total environment
- Publication Type :
- Academic Journal
- Accession number :
- 37245825
- Full Text :
- https://doi.org/10.1016/j.scitotenv.2023.164305