Di-fluoro azepane HBV capsid assembly modulators.

Authors :: DeRatt LG
Stoops B
Shaffer P
Lam AM
Espiritu C
Vogel R
Lau V
Flores OA
Kuduk SD
Source :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Aug 15; Vol. 92, pp. 129350. Date of Electronic Publication: 2023 May 27.
Publication Year :: 2023
Abstract: The protein that forms the inner shell of the HBV virus, known as the capsid core protein, plays a crucial role in allowing chronic HBV infections to persist. Studies have shown that disrupting the assembly of the capsid can effectively combat the virus, and small molecule drugs that target the HBV capsid assembly modulator (CAM) process have been successful in clinical trials. Herein is described a distinct series of di-fluoro azepane CAMs with exceptional potency, pharmacokinetic, and solubility properties.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)