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Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice.
- Source :
-
Nature communications [Nat Commun] 2023 May 29; Vol. 14 (1), pp. 3076. Date of Electronic Publication: 2023 May 29. - Publication Year :
- 2023
-
Abstract
- Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to restrain kisspeptin (KISS1)-neuron pulsatility in the arcuate hypothalamic nucleus, while also exerting a surge-like effect on KISS1-neuron activity in the AVPV hypothalamic nucleus. However, a mechanistic basis for this region-specific effect has remained elusive. Our genomic analysis in female mice demonstrate that some processes, such as restraint of KISS1-neuron activity in the arcuate nucleus, may be explained by region-specific estrogen receptor alpha (ERα) DNA binding at gene regulatory regions. Furthermore, we find that the Kiss1-locus is uniquely regulated in these hypothalamic nuclei, and that the nuclear receptor co-repressor NR0B1 (DAX1) restrains its transcription specifically in the arcuate nucleus. These studies provide mechanistic insight into how ERα may control the KISS1-neuron, and Kiss1 gene expression, to couple gonadotropin release to the developmental stage of the oocyte.<br /> (© 2023. The Author(s).)
- Subjects :
- Animals
Female
Mice
Arcuate Nucleus of Hypothalamus metabolism
Estradiol metabolism
Estrogens metabolism
Estrogen Receptor alpha genetics
Estrogen Receptor alpha metabolism
Hypothalamus metabolism
Kisspeptins genetics
Kisspeptins metabolism
DAX-1 Orphan Nuclear Receptor genetics
DAX-1 Orphan Nuclear Receptor metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 37248237
- Full Text :
- https://doi.org/10.1038/s41467-023-38618-y