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The effect of synthetic androgens on the hypothalamic-pituitary-gonadal axis in boys with constitutionally delayed growth.
- Source :
-
The Journal of pediatrics [J Pediatr] 1979 Apr; Vol. 94 (4), pp. 657-62. - Publication Year :
- 1979
-
Abstract
- Serial concentrations of basal serum LH, FSH, testosterone, and LH and FSH responses to intravenous gonadotropin-releasing hormone were measured before and during six months of administration of fluoxymesterone or oxandrolone in 14 boys with constitutionally delayed growth and adolescence, in order to assess the effects of these androgens on maturation of the hypothalamic-pituitary-gonadal axis. Before therapy all boys had normal hormonal responses based on bone age. At the end of six months therapy 10 of the 14 boys had lower LH responses (34 to 89% reduction) to GnRH without consistent changes in FSH responses. With both androgens, there there was significant suppression of both basal serum FSH and testosterone. Eleven boys were restudied six months after completion of therapy; basal serum LH, FSH, and testosterone and responses to GnRH were equal to or greater than pretreatment levels, indicating recovery or progressive maturation of the HPGA. All boys had increased growth velocity and imporved weight gain without excessive bone age advancement; all had improved psychosocial adjustment.
- Subjects :
- Adolescent
Child
Fluoxymesterone therapeutic use
Follicle Stimulating Hormone blood
Follicle Stimulating Hormone metabolism
Growth Disorders drug therapy
Growth Disorders psychology
Humans
Luteinizing Hormone blood
Luteinizing Hormone metabolism
Male
Oxandrolone therapeutic use
Pituitary Hormone-Releasing Hormones
Puberty drug effects
Testosterone blood
Testosterone metabolism
Fluoxymesterone pharmacology
Growth Disorders physiopathology
Hypothalamo-Hypophyseal System drug effects
Oxandrolone pharmacology
Testis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3476
- Volume :
- 94
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 372514
- Full Text :
- https://doi.org/10.1016/s0022-3476(79)80046-3