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The Histopathology of Cold Agglutinin Disease-Associated B-Cell Lymphoproliferative Disease.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 2023 Sep 01; Vol. 160 (3), pp. 229-237. - Publication Year :
- 2023
-
Abstract
- Objectives: Primary cold agglutinin disease is a type of autoimmune hemolytic anemia caused by circulating antibodies against I antigen, a carbohydrate expressed on most cells, including red blood cells. The underlying disease has been characterized in recent years as a distinct B-cell lymphoproliferative disease of the bone marrow, occurring mostly in the elderly. The disease has been now been included as a separate entity in the most recent classifications of mature B-cell neoplasms.<br />Methods: A review of the characteristics of cold agglutinin disease is provided, with an emphasis on the pathology features.<br />Results: A detailed description of the histopathology, immunophenotype, and genetics of cold agglutinin disease is provided and compared to other B-cell lymphoproliferative diseases in the bone marrow with similar features.<br />Conclusions: Recognition of the pathology features of cold agglutinin disease allows to distinguish it from other diseases, especially lymphoplasmacytic lymphoma and marginal zone lymphoma.<br /> (© The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Details
- Language :
- English
- ISSN :
- 1943-7722
- Volume :
- 160
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 37253147
- Full Text :
- https://doi.org/10.1093/ajcp/aqad048