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Disruption of locus coeruleus-related functional networks in Parkinson's disease.
- Source :
-
NPJ Parkinson's disease [NPJ Parkinsons Dis] 2023 May 30; Vol. 9 (1), pp. 81. Date of Electronic Publication: 2023 May 30. - Publication Year :
- 2023
-
Abstract
- Locus coeruleus (LC) is severely affected in Parkinson's Disease (PD). However, alterations in LC-related resting-state networks (RSNs) in PD remain unclear. We used resting-state functional MRI to investigate the alterations in functional connectivity (FC) of LC-related RSNs and the associations between RSNs changes and clinical features in idiopathic rapid eye movement sleep behavior disorder (iRBD) and PD patients with (PD <superscript>RBD+</superscript> ) and without RBD (PD <superscript>RBD-</superscript> ). There was a similarly disrupted FC pattern of LC-related RSNs in iRBD and PD <superscript>RBD+</superscript> patients, whereas LC-related RSNs were less damaged in PD <superscript>RBD-</superscript> patients than that in patients with iRBD and PD <superscript>RBD+</superscript> . The FC of LC-related RSNs correlated with cognition and duration in iRBD, depression in PD <superscript>RBD-</superscript> , and cognition and severity of RBD in patients with PD <superscript>RBD+</superscript> . Our findings demonstrate that LC-related RSNs are significantly disrupted in the prodromal stage of α-synucleinopathies and proposed body-first PD (PD <superscript>RBD+</superscript> ), but are less affected in brain-first PD (PD <superscript>RBD-</superscript> ).<br /> (© 2023. The Author(s).)
Details
- Language :
- English
- ISSN :
- 2373-8057
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- NPJ Parkinson's disease
- Publication Type :
- Academic Journal
- Accession number :
- 37253752
- Full Text :
- https://doi.org/10.1038/s41531-023-00532-x