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Mediastinal parathyroid carcinoma: a case report and review of the literature.
- Source :
-
BMC endocrine disorders [BMC Endocr Disord] 2023 Jun 06; Vol. 23 (1), pp. 130. Date of Electronic Publication: 2023 Jun 06. - Publication Year :
- 2023
-
Abstract
- Background: Parathyroid carcinoma (PC) is an uncommon cause of primary hyperparathyroidism (PHPT) and particularly rare in the mediastinum. Herein, we present a case of mediastinal PC and conduct a related literature review.<br />Case Presentation: We described a case of a 50-year-old female patient with PHPT due to mediastinal PC. She was initially admitted to a local hospital in her hometown with hypercalcemia and high blood concentrations of PTH (parathyroid hormone). The patient underwent neck parathyroidectomy and pathological examination suggested parathyroid adenoma. Although the overproduction of serum calcium and PTH declined after the surgery, calcium and PTH increased again one month later, so the patient was transferred to our hospital. A 99 <superscript>m</superscript> Tc-sestamibi scan revealed an ectopic finding in the mediastinum, which was also indicated on the CT image. After removing the mediastinal mass, the metabolism of calcium and PTH quickly reverted to normal and the pathologic features of the mass were consistent with PC. By reviewing the related literature, we noticed that only scattered reports were published before 1982, and those were not included in the present review due to their differences with current radiological examination and treatment methods. After excluding outdated studies, we summarized and analyzed 20 reports of isolated mediastinal PC and concluded that. Parathyroidectomy remains the only curative treatment for the disease. Furthermore, the success of treatment directly depends on accurate preoperative localization.<br />Conclusion: With this study, we emphasize the importance of accurate preoperative diagnosis of mediastinal PC and improve clinicians' understanding of the disease.<br /> (© 2023. The Author(s).)
- Subjects :
- Humans
Female
Middle Aged
Mediastinum diagnostic imaging
Mediastinum pathology
Mediastinum surgery
Calcium
Parathyroid Hormone
Parathyroidectomy adverse effects
Parathyroid Neoplasms diagnosis
Parathyroid Neoplasms diagnostic imaging
Hyperparathyroidism, Primary diagnosis
Hyperparathyroidism, Primary etiology
Hyperparathyroidism, Primary surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1472-6823
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC endocrine disorders
- Publication Type :
- Academic Journal
- Accession number :
- 37280629
- Full Text :
- https://doi.org/10.1186/s12902-023-01363-w