ALSUntangled #70: caffeine.

Authors :: Hatch J
Barkhaus P
Barnes B
Beauchamp M
Benatar M
Bertorini T
Bowser R
Bromberg M
Brown A
Mascias Cadavid J
Carter GT
Cole N
Crayle J
Dimachkie M
Ennist D
Feldman E
Fullam T
Heiman-Patterson T
Jhooty S
Levine T
Li X
Lund I
Mallon E
Maragakis N
McDermott C
Pattee G
Pierce K
Ratner D
Staats K
Wicks P
Wiedau M
Bedlack R
Source :: Amyotrophic lateral sclerosis & frontotemporal degeneration [Amyotroph Lateral Scler Frontotemporal Degener] 2023 Jun 08, pp. 1-5. Date of Electronic Publication: 2023 Jun 08.
Publication Year :: 2023
Publisher :: Ahead of Print
Abstract: ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here, we review caffeine which has plausible mechanisms for slowing ALS progression. However, pre-clinical studies are contradictory, and a large case series showed no relationship between caffeine intake and ALS progression rate. While low doses of caffeine are safe and inexpensive, higher doses can cause serious side effects. At this time, we cannot endorse caffeine as a treatment to slow ALS progression.