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Primary antibiotic resistance in Helicobacter pylori in China: a systematic review and meta-analysis.
- Source :
-
Journal of global antimicrobial resistance [J Glob Antimicrob Resist] 2023 Sep; Vol. 34, pp. 30-38. Date of Electronic Publication: 2023 Jun 12. - Publication Year :
- 2023
-
Abstract
- Objectives: The incidence of Helicobacter pylori (HP) is 25-50% in developed countries and 80% in developing countries, including 56.2% in China. However, antibiotic resistance of HP is a threat to HP control. The purpose of this study was to comprehensively evaluate primary drug resistance of HP in China.<br />Methods: The full text of reports of the primary antibiotic resistance prevalence of HP was obtained from multiple databases (PubMed, Web of Science, Evimed, Cochrane Library, and China National Knowledge Internet). Review Manager 5.2 was adopted for meta-analysis, sensitivity analysis, and bias analysis. The Newcastle-Ottawa Scale was used to assess the article quality.<br />Results: In total, 38804 HP samples from 22 trials were extracted. The results suggested that the overall prevalence of amoxicillin, clarithromycin, metronidazole, and levofloxacin resistance among HP in adults was as follows: mean difference (MD) = 1.35%, 95% confidence interval (CI) [1.03%, 1.68%]; MD = 23.76%, 95% CI [20.23%, 27.3%]; MD = 69.32%, 95% CI [64.85%, 73.8%]; and MD = 29.45%, 95% CI [4.90, 176.96], respectively. From the results of sensitivity and publication bias, we find that these results are robust and had little publication bias.<br />Conclusion: Our research showed that in China, the prevalence of HP resistance to primary antibiotics warrants attention, especially with regard to metronidazole, levofloxacin, and clarithromycin.<br /> (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Adult
Humans
Metronidazole pharmacology
Clarithromycin pharmacology
Levofloxacin pharmacology
Drug Resistance, Bacterial
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents therapeutic use
China epidemiology
Helicobacter pylori genetics
Helicobacter Infections epidemiology
Helicobacter Infections drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2213-7173
- Volume :
- 34
- Database :
- MEDLINE
- Journal :
- Journal of global antimicrobial resistance
- Publication Type :
- Academic Journal
- Accession number :
- 37315738
- Full Text :
- https://doi.org/10.1016/j.jgar.2023.05.014