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Designed synthesis of prussian blue@Cu-doped zinc phosphate nanocomposites for chemo/chemodynamic/photothermal combined cancer therapy.
- Source :
-
Journal of materials chemistry. B [J Mater Chem B] 2023 Jul 12; Vol. 11 (27), pp. 6404-6411. Date of Electronic Publication: 2023 Jul 12. - Publication Year :
- 2023
-
Abstract
- Designing a multifunctional nanoplatform that combines multiple treatments has emerged as an innovative cancer treatment strategy. A simple and clear route is put forward to develop Cu <superscript>2+</superscript> -doped zinc phosphate coated prussian blue nanoparticles (designated as PB@Cu <superscript>2+</superscript> /ZnP NPs) integrating tri-modal therapy (chemo, chemodynamic and photothermal therapy) for maximizing anti-tumor efficacy. The obtained PB@Cu <superscript>2+</superscript> /ZnP NPs possess drug loading capacity due to the mesoporous structure present in the Cu <superscript>2+</superscript> -doped ZnP shell. In addition, the Cu <superscript>2+</superscript> -doped ZnP shell can gradually degrade in response to the mildly acidic tumor microenvironment to release DOX and Cu <superscript>2+</superscript> , where the released drug plays the role of chemotherapy agent and the Cu <superscript>2+</superscript> can react with intracellular glutathione to achieve a Cu-mediated Fenton-like reaction for chemodynamic therapy. Moreover, under laser irradiation, the heat garnered by the photothermal conversion of PB can be applied for photothermal therapy and enhance the generation of toxic ˙OH as well as the amount of DOX released, further boosting chemo- and chemodynamic therapy to realize a combined therapy. Importantly, the PB@Cu <superscript>2+</superscript> /ZnP NPs effectively limit the growth of tumors via the coordinated action of chemo/chemodynamic/photothermal therapy and no noticeable systematic toxicity can be found in mice. Taken together, the PB@Cu <superscript>2+</superscript> /ZnP NPs can act as a prospective therapeutic nanoplatform for multi-modal therapy of tumors.
Details
- Language :
- English
- ISSN :
- 2050-7518
- Volume :
- 11
- Issue :
- 27
- Database :
- MEDLINE
- Journal :
- Journal of materials chemistry. B
- Publication Type :
- Academic Journal
- Accession number :
- 37338519
- Full Text :
- https://doi.org/10.1039/d3tb00342f