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Intracellular Delivery of an Antibody-Like Molecule Capable of Inhibiting c-Myc.
- Source :
-
Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2023 Apr; Vol. 509 (1), pp. 70-72. Date of Electronic Publication: 2023 Jun 20. - Publication Year :
- 2023
-
Abstract
- A modular nanotransporter (MNT) carrying the sequence of an antibody-like molecule, anti-c-Myc nanobody, was synthesized and characterized. It was demonstrated that the created MNT is able to interact with the target protein, c-Myc oncogene, with a dissociation constant of 46 ± 14 nM, internalize into target cells, change Myc-dependent expression, and exert an antiproliferative effect.<br /> (© 2023. Pleiades Publishing, Ltd.)
Details
- Language :
- English
- ISSN :
- 1608-3091
- Volume :
- 509
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Doklady. Biochemistry and biophysics
- Publication Type :
- Academic Journal
- Accession number :
- 37340296
- Full Text :
- https://doi.org/10.1134/S1607672923700114