Back to Search
Start Over
Cow's milk allergy: Can oral food challenges be avoided? A probabilistic analysis based on clinical data.
- Source :
-
Archivos argentinos de pediatria [Arch Argent Pediatr] 2023 Dec 01; Vol. 121 (6), pp. e202202850. Date of Electronic Publication: 2023 Jun 29. - Publication Year :
- 2023
-
Abstract
- Introduction. The oral food challenge (OFC) for the diagnosis of cow's milk protein allergy (CMPA) poses risks and requires resources. Our objective was to assess conditions and complementary tests used to identify a high probability of CMPA. Population and methods. Secondary analysis of a study of patients seen at a unit of allergy between 2015 and 2018. Pre-testing probabilities associated with symptoms and their combinations and post-testing probabilities after skin prick testing and serum immunoglobulin E (IgE) levels were determined. Results. The data from 239 patients were assessed. A probability greater than 95% was observed for angioedema and a combination of urticaria and vomiting. Based on the cut-off points proposed by Calvani et al., the combination of vomiting with rhinitis, without angioedema, also exceeded 95%. Conclusion. A methodology is provided to identify patients in whom CMPA may be diagnosed without an OFC.<br /> (Sociedad Argentina de Pediatría.)
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 1668-3501
- Volume :
- 121
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Archivos argentinos de pediatria
- Publication Type :
- Academic Journal
- Accession number :
- 37342978
- Full Text :
- https://doi.org/10.5546/aap.2022-02850.eng