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Tooth loss impairs cognitive function in SAMP8 mice via the NLRP3/Caspase-1 pathway.
- Source :
-
Oral diseases [Oral Dis] 2024 May; Vol. 30 (4), pp. 2746-2755. Date of Electronic Publication: 2023 Jun 25. - Publication Year :
- 2024
-
Abstract
- Objective: Loss of occlusal support due to tooth loss has been indicated as one of the risk factors for Alzheimer's disease. This study aimed to investigate the relationship between tooth loss and cognitive dysfunction and illustrate the role of neuroinflammation in advancing Alzheimer's disease.<br />Materials and Methods: Male 5-month-old senescence-accelerated mouse strain P8 (SAMP8) mice were divided into three groups (n = 7): the C (control), S (sham-operated), and TL (tooth loss) groups. The Morris water maze (MWM) test was performed to assess spatial memory. Additionally, histopathological and molecular assessments of hippocampal tissues were performed.<br />Results: The TL groups exhibited impaired spatial memory in the water maze. Tooth loss induced higher protein expression levels of the neuroinflammation cytokine interleukin-1β (IL-1β) in the hippocampus than in the S and C groups. Tooth loss activated the NLRP3 inflammasome and increased the expression of Caspase-1 in the hippocampus.<br />Conclusions: The findings indicated that tooth loss impairs cognitive function in SAMP8 mice and is closely related to the activation of NLRP3/Caspase-1 in the hippocampus.<br /> (© 2023 Wiley Periodicals LLC.)
- Subjects :
- Animals
Mice
Male
Cognitive Dysfunction etiology
Cognitive Dysfunction metabolism
Inflammasomes metabolism
Maze Learning
Cognition
Signal Transduction
Spatial Memory
Alzheimer Disease metabolism
NLR Family, Pyrin Domain-Containing 3 Protein metabolism
Caspase 1 metabolism
Tooth Loss etiology
Tooth Loss complications
Hippocampus metabolism
Interleukin-1beta metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1601-0825
- Volume :
- 30
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Oral diseases
- Publication Type :
- Academic Journal
- Accession number :
- 37357357
- Full Text :
- https://doi.org/10.1111/odi.14646