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Anti-Inflammatory Steroids from the South China Sea Soft Coral Lobophytum sarcophytoides.
- Source :
-
Chemistry & biodiversity [Chem Biodivers] 2023 Aug; Vol. 20 (8), pp. e202300821. Date of Electronic Publication: 2023 Jul 06. - Publication Year :
- 2023
-
Abstract
- Three new steroids, along with two known related analogs, were isolated from the Xisha Island soft coral Lobophytum sarcophytoides. The structures and absolute configurations of the new compounds were elucidated by extensive spectroscopic data analyses, time dependent density functional theory electronic circular dichroism calculation, and comparison with the spectral data previously reported in the literature. In in vitro bioassay, four compounds showed interesting suppressive effects on lipopolysaccharide (LPS) induced inflammation in BV-2 microglial cells at 10 μM level.<br /> (© 2023 Wiley-VHCA AG, Zurich, Switzerland.)
Details
- Language :
- English
- ISSN :
- 1612-1880
- Volume :
- 20
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Chemistry & biodiversity
- Publication Type :
- Academic Journal
- Accession number :
- 37376927
- Full Text :
- https://doi.org/10.1002/cbdv.202300821