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Ocular candidiasis in a tertiary hospital in Japan: A 10-year single-center retrospective study.
- Source :
-
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [J Infect Chemother] 2023 Nov; Vol. 29 (11), pp. 1081-1087. Date of Electronic Publication: 2023 Jun 29. - Publication Year :
- 2023
-
Abstract
- Ocular candidiasis is a major complication of candidemia that is sometimes sight-threatening. Although prompt ophthalmologic consultation and antifungal medication have been emphasized, recent changes in the causative species and drug susceptibilities make the picture unclear. This study aimed to determine whether there are trends among patients with ocular candidiasis and included 80 patients with candidemia who underwent ophthalmological screening at our hospital between 2010 and 2020. Data on the clinical characteristics, comorbidities, biochemical test results, causative Candida species, treatment, outcomes, visual acuity, and antifungal susceptibility were collected and analyzed. Statistical analyses were performed by comparing two groups, namely, the ocular candidiasis (n = 29) and non-ocular candidiasis (n = 51) groups. In the ocular candidiasis group, there were significantly more cases of central venous catheter insertion (82.8%, p = 0.026) and Candida albicans candidemia (72.4%, p < 0.001). Regarding ocular involvement, the majority of patients were asymptomatic. Most cases improved with antifungal therapy, but one case underwent vitrectomy. Between 2016 and 2020, there was a diversification of species, with a decrease in Candida parapsilosis and the emergence of Candida glabrata and Candida tropicalis. Regarding drug susceptibility, the minimum inhibitory concentrations of echinocandin and 5-fluorocytosine against Candida albicans, Candida parapsilosis, and Candida glabrata were slightly increased. In conclusion, in addition to appropriately performing ophthalmologic examinations, it is beneficial to select antifungal agents according to the diversity of species and drug susceptibilities.<br />Competing Interests: Declaration of competing interest The authors declare that they have no competing interests.<br /> (Copyright © 2023 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Antifungal Agents pharmacology
Antifungal Agents therapeutic use
Retrospective Studies
Tertiary Care Centers
Japan epidemiology
Candida albicans
Candida glabrata
Candida parapsilosis
Microbial Sensitivity Tests
Candidemia drug therapy
Candidiasis drug therapy
Candidiasis epidemiology
Endophthalmitis drug therapy
Eye Infections, Fungal drug therapy
Eye Infections, Fungal epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7780
- Volume :
- 29
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 37392844
- Full Text :
- https://doi.org/10.1016/j.jiac.2023.06.019